The Blues are rapidly reproducing; growing more intelligent and lethal each day. With hundreds of millions still covering the earth, the future of humankind looks bleak. Yet, Bruce and his Clan refuse to die without a fight to the bitter end. The elite squads of Omega and Gamma protect the remaining uninfected as the Clan works to rebuild America. As the Blues swarm, the Clan will not emerge unscathed. 

Meanwhile, the remnants of the US government are experimenting on Blues, teaching them how to fire weapons. It's up to Bruce and his team to stop this atrocity before they lose the only advantage they have over the Blues. They have no idea that what they find will change the course of the human race forever. In the final stand against the Blue Plague, Bruce, his family, and the Clan are the last bastion of Hope in the ravaged world.