Following her escape from the Nemesis monster and the subsequent destruction of Raccoon City, Jill Valentine is on the run for her life. Haunted by her experiences and hunted by those she has sworn to take down, she has managed to stay one step ahead of her pursuers until she is finally tracked down. But will this mysterious encounter prove to be her undoing, or a chance for redemption?

Taking place between the events of Resident Evil 3: Nemesis and Resident Evil 5, Foundations is the story of one of the series' most prominent characters finding their way back to the light.