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CLOT Conversations

Thrombosis Canada

Released: 2022-04-21

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5 Episodes

Audio

Free New

5 Episodes

Audio

Released: 2022-04-21

Most Recent Episode

Anti-seizure & Anticoagulant medications & interactions

Time: 30:42

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This is Episode 4 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Vinai Bhagirath and Dr Sam Schulman, two of the authors of a recently published paper entitled Carbamazepine, phenytoin, and oral anticoagulants: Drug-drug interaction and clinical events in a retrospective cohort. The paper was published in Research and Practice in Thrombosis and Haemostasis (Res Pract Thromb Haemost. 2022;6:e12650. https://doi.org/10.1002/rth2.12650)

The authors discuss the results of the retrospective cohort of patients taking carbamazepine or phenytoin with warfarin or DOACs. In particular, they explore whether there is a relationship between anticoagulant levels and thromboembolic events. Dr Schulman and Dr Bhagirath discuss their perspectives on the issues relevant to each type of anticoagulant when used in patients on anti-seizure medications and what their study added to the understanding of drug-drug interactions.

Dr Sam Schulman graduated from Karolinska Institutet, Stockholm, Sweden in 1977 and has worked with coagulation disorders since 1984. Research activities have been clinical studies in venous thromboembolism, in hemophilia and bleeding.

He has been a member of the Executive Committee of the World Federation of Hemophilia, was President for the XXV ISTH Congress, Toronto, 2015, is member of the ISTH Council and Treasurer. In 2017 he received Harold R. Roberts medal of the ISTH SSC.

He is Director of the Thrombosis Service at Hamilton General Hospital and professor in Medicine at McMaster University, Hamilton, Canada, and at Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia.

Dr Vinai Bhagirath, is a Thrombosis physician at Hamilton Health Sciences and Assistant Professor of Medicine at McMaster University. His research interests include bleeding risk with anticoagulants and clinical measurement of DOAC drug levels. His quality improvement interests include optimization of medical therapy in peripheral artery disease and standardization of periprocedural management of antithrombotic medications. His educational activities include Directorship of Thrombosis Fellowship programs at McMaster, and he is co-chair of the upcoming 2022 THSNA Summit and chair of Thrombosis Canada's Continuing Professional Development committee.

Thrombosis Canada Tools related to the content:

DOAC Drug Interaction tool: https://thrombosiscanada.ca/wp-uploads/uploads/2021/09/DDI-Tool-Final-English.pdf

Thrombosis Canada Clinical Guides: https://thrombosiscanada.ca/clinicalguides/

Thrombosis Canada: @ThrombosisCan

Sam Schulman: @SamSchulman6

Reference:

Candeloro, M., Eikelboom, J. W., Chan, N., Bhagirath, V., Douketis, J. D., & Schulman, S. (2022). Carbamazepine, phenytoin, and oral anticoagulants: Drug‐drug interaction and clinical events in a retrospective cohort. Research and Practice in Thrombosis and Haemostasis, 6(2), e12650.

Support the show (https://www.paypal.com/donate/?hosted_button_id=TXZVV2JPJ3W8G)

Episode ID: 1000558300489

GUID: Buzzsprout-10479562

Release Date: 21/04/2022, 17:00:00

Description

CLOT Conversations from Thrombosis Canada is a regular podcast for healthcare professionals exploring advances in the diagnosis and management of thrombosis, with a focus on new research as it is published. Our 15 to 20 minute easily digestible episodes will help keep you up to date on the evolving practice in this challenging field. Listen to thrombosis experts as they discuss their latest research with hosts Dr Jameel Abdulrehman, Hematologist with specialization in Thrombosis and Hemostasis at the University Health Network in Toronto, Canada and David Airdrie, Executive Director of Thrombosis Canada Thrombosis Canada promotes excellent patient care and improved outcomes for patients with thrombosis through high-quality knowledge translation, educational resources, and point-of-care guidance for diverse groups of healthcare professionals. We also provide education for patients and the general public. This podcast is another way for us to support those seeking to learn more and keep up with new developments. To access Thrombosis Canada resources, tools, and programs go to https://thrombosiscanada.ca

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