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Haemline

Haemline

Released: 2025-07-20
© 2025 Haemline
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11 Episodes
Audio
Listen on Apple Podcasts
11 Episodes
Audio
Listen on Apple Podcasts
Released: 2025-07-20
© 2025 Haemline
Most Recent Episode
First-Line Ven/Aza/Revumenib for AML?

First-Line Ven/Aza/Revumenib for AML?

Could targeting the menin–KMT2A axis up front improve outcomes in older adults with NPM1-mutated or KMT2A-rearranged AML? In this episode, we examine new phase I data from Zeidner and colleagues, published in The Journal of Clinical Oncology in June 2
Time: 12:26
Could targeting the menin–KMT2A axis up front improve outcomes in older adults with NPM1-mutated or KMT2A-rearranged AML? In this episode, we examine new phase I data from Zeidner and colleagues, published in The Journal of Clinical Oncology in June 2025, investigating revumenib in combination with azacitidine and venetoclax for newly diagnosed patients ineligible for intensive therapy.
We explore the shared biological mechanism linking these two subtypes, the rationale for adding menin inhibition to ven/aza, and early results—including high remission rates, MRD nuances, and challenges around myelosuppression and treatment delays.
How do these outcomes compare to VIALE-A? Could molecular MRD clearance inform future consolidation strategies? And where might this triplet fit among the growing field of ven/aza-based combinations?
Episode type: Deep Dive potentially relevant to anyone carrying for acute leukaemia patients or interested in menin inhibitors more generally.
Episode ID: 1000718155822
GUID: Buzzsprout-17532645
Release Date: 20/07/2025, 15:00:00

Description

Haematology learning on-the-go, made by UK haematologists who know you're busy, tired, and possibly holding a sandwich. Whether you're commuting, tidying up, or too spent to open a book, we aim to deliver short episodes to fit into your daily grind. From blood basics to niche deep dives, there's something for students, specialists, and the haemo-curious. Most episodes are tightly scripted for a solo host, crafted to feel like a clear, helpful colleague talking it through. Designed to support evidence-based thinking habits that outlast outdated exam knowledge. New episodes most weeks.

Apple Podcasts: Customer Reviews

2025-07-13

Fun haematology learning on-the-go

This is an excellent podcast. Concise yet comprehensive and fun. Scientific concepts are explained with relatable analogies so the content sticks in your mind. I‘m looking forward to more episodes 😃!
Latlingot