House and the team take on the case of a struggling artist (guest star Breckin Meyer) who has been painting bizarre portraits. His undiagnosed illness is distorting his perception, threatening to undermine his career, his relationships and everything else in his life. The team soon finds out that he hasn't sold anything lately and is on three separate drug trials to pay the bills. House must unlock the puzzle of which drugs are causing which symptoms before it's too late. Meanwhile, House continues to have private investigator Lucas Douglas (guest star Michael Weston) dig up dirt on everyone on his team, including Taub who is having trouble in his marriage in the "Adverse Events" episode of House.